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What vitamin helps with mood swings? 8 Mood-Supporting Vitamins and Supplements Magnesium. You've heard that bathing in Epsom salts (which contain the mineral magnesium sulfate) helps to soothe achy muscles, of course. Vitamin D. Ashwagandha. Rhodiola. Passionflower. St. John's wort. SAM-e. Omega-3s.